Hif1a是什么蛋白

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August undefined, 2024

Web7 de jun. de 2013 · STUB1 is a critical player in the CMA-dependent degradation of HIF1A. ARPE-19 cells were transfected with STUB1-myc and incubated either in the presence or absence of 200 μM chloroquine, 20 μM MG-132 or 2% O 2 for 8 h or 300 μM CoCl 2 for 6 h. ( A) Immunoprecipitation of myc-tagged STUB1. WebHypoxia-inducible factor 1 (HIF1) is a heterodimeric transcription factor that plays a critical role in the cellular response to hypoxia (1). The HIF1 complex consists of two subunits, HIF-1α and HIF-1β, which are basic helix-loop …

Cell Stem Cell HIF1a的非经典靶标损害少突胶质祖细胞 ...

WebReceive email alerts when new plasmids with this gene become available. Log in to subscribe to Addgene Alerts. Description hypoxia inducible factor 1 subunit alpha. Also … Web10 de abr. de 2024 · Organism. Lineage. Also known as. HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; HIF-1-alpha. Summary. This gene encodes the … meteorology jobs in botswana

HIF1A siRNAs

Web25 de mar. de 2024 · We obtained femoral heads from Col2a1-Cre ERT2; Hif1a fl/fl (KO) and Hif1a fl/fl (Cntl) mice after tamoxifen treatment, and cultured them with or without IL-1β under hypoxia. Web21 de mar. de 2024 · HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Retinal Ischemia and … Web17 de jan. de 2024 · Taken together, this study demonstrates the key function of the hypoxia-associated transcription factor HIF-1α in driving IL-10 expression in CD1d hi CD5 + B cells, and in controlling their... meteorology education and training

HIF1A - an overview ScienceDirect Topics

HIF1A protein expression summary - The Human Protein Atlas

WebFurthermore, HIF1A expression was found to be positively associated with both tumor immune infiltration and PD-L1 expression, indicating that tumors with elevated expression of HIF1A may exhibit a more active immunotherapy response. This indication was substantiated in a kidney cancer cohort receiving anti-PD-1/PD-L1 immunotherapy. WebThe transcription factor hypoxia inducible factor-1α (HIF-1α) mediates adaptive responses to oxidative stress by nuclear translocation and regulation of gene expression. … how to add a drop line in microsoft projectWeb26 de fev. de 2024 · To investigate the contributions of HIF-1α in regulating glycolysis of cancer cells under hypoxia, we evaluated the dynamics of HIF-1α protein and its target … meteorology job outlook

"Web25 de mar. de 2024 · Abstract. HIF-1α, an essential transcription factor under hypoxic condition, is indispensable for chondrocytes during skeletal development but its … " - Hif1a是什么蛋白

Hif1a是什么蛋白

HIF1A hypoxia inducible factor 1 subunit alpha [ (human)]

Web14 de dez. de 2024 · 以上数据表明，HIF1a累积引起的Sox10表达降低对于少突胶质细胞分化中HIF介导的阻滞至关重要，在不改变sgVhl OPC中经典HIF功能的情况下恢复Sox10表达可恢复少突胶质细胞的形成。. 最后，为了评估MEK抑制在低氧人脑OPC中的作用，作者利用先前建立的从多能干细胞中 ...

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WebFull gene name according to HGNC. Hypoxia inducible factor 1 subunit alpha. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to … WebIldus I. Ahmetov, Olga N. Fedotovskaya, in Advances in Clinical Chemistry, 2015 2.14 HIF1A Pro582 Allele. Hypoxia-inducible factor-1α (HIF-1α; encoded by HIF1A; location: 14q23.2) is a transcription factor regulating several genes in response to hypoxic stimuli.HIF-1α mRNA and protein levels were found to be constitutively higher in the …

Web20 de dez. de 2024 · 细胞信号通路详解之HIF1α通路. 动物细胞中，对氧气的感知和反应是一个非常重要的过程，在包括癌症、心血管疾病和中风在内的多种疾病的病理生理学中占 … WebHIF-1 alpha是HIF-1蛋白亚基，由HIF1A基因编码。 HIF-1 alpha是细胞在缺氧条件下生存能力的重要转录调节因子。 HIF-1 alpha在血管形成中起重要作用，其失调与癌症和缺血性 …

Web7 de set. de 2024 · HIF-1通过激活NAFLD中lipin1的表达和核积累，在过氧化物酶体脂代谢的调控中发挥了关键作用。. Hif-1α基因缺失通过激活lipin1 的表达来抑制过氧化物酶体脂肪酸氧化，进而抑制异常脂质积累，这提示lipin1可能是HIF-1α的一个靶基因[4]。. 最近的一项研究 … Web21 de mar. de 2024 · HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Retinal Ischemia and Enchondromatosis, Multiple, Ollier Type.Among its related pathways are Signaling by PTK6 and Regulation of activated PAK-2p34 by proteasome mediated degradation.Gene …

WebCatalog #. AM16708. Standard 5 nmol. Purification: HPLC In-Vivo Ready Standard. Size: 5 nmol 20 nmol 20 nmol 20 nmol 20 nmol 40 nmol 40 nmol 100 nmol 250 nmol 250 nmol 1 umol 10 umol. Availability: Inventoried.

Web3 de mar. de 2024 · Hypoxia-inducible factor 1 (HIF1) is a heterodimeric transcription factor, consisting of a constitutively expressed β-subunit (HIF1B) and a regulated α-subunit … how to add ads in youtube videoWebHypoxia inducible factor (HIF)-1 and HIF-2 are heterodimeric transcription factors mediating the cellular response to hypoxia. Recent data indicate that not only ubiquitous HIF-1 alpha, but also more cell-specific HIF-2 alpha, is an important regulator of the hypoxia response. Although both alpha su … meteorology jobs in canadaWeb因为依赖氧气，所以氧气不足——氧气浓度不断降低的时候，HIF-1α的泛素化就会减少，于是HIF-1α的分解就会减少，而合成速率不变或者通过某些继发的转录或者翻译调节途径而增加，因此HIF-1α的浓度迅速增加，从而到细胞核里去促进转录等等。. 研究发现HIF-1α ... how to add ads in youtubeWebAbout This Kit. The Human HIF1A ELISA quantitates Hu HIF1A in human serum, plasma, or cell culture lysates. The assay will exclusively recognize both natural and recombinant Hu HIF1A. The Human HIF1A solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched … how to add adsense to your youtube channelWebInteracts with the ARNT; forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371). Interacts with COPS5; the interaction increases the transcriptional activity of HIF1A through increased stability (PubMed:11707426). Interacts with EP300 (via TAZ-type 1 domains); … how to add ads in wordpressWebHIF-1α は，低酸素誘導因子 HIF-1 の α サブユニットである。 HIF-1 は低酸素 hypoxia への適応に必要な遺伝子の転写を促進する転写因子 transcription factor で，α サブユニット（HIF-1α）と β サブユニット（HIF-1β）から成る。このうち α サブユニットは，以下のように水酸化修飾を受けて常に分解され ... meteorology is the studyWeb3 de abr. de 2024 · HIF1A Knockout by Biallelic and Selection-Free CRISPR Gene Editing in Human Primary Endothelial Cells with Ribonucleoprotein Complexes. Association of … meteorology meaning in marathi